PBS-MiniPRO
Combines closed operation, parallel bioprocessing, automation, and advanced process control into a high-throughput, 1 - 24 vessel bioreactor platform with our patented Vertical-Wheel® Technology.
Why MiniPRO
MiniPRO is designed for teams that need more than proof of concept. By combining automation, process control, and high-throughput experimentation in a scalable, closed bioreactor platform, MiniPRO accelerates optimization, reduces development risk, and generates data with greater manufacturing relevance.
Run 1 to 24 independent bioreactors in parallel to accelerate screening, optimization, and DoE studies. A single MiniPRO Controller Module runs up to six MiniPRO Housing units (four bioreactors per Housing unit).
Rockwell FactoryTalk® industrial automation and manufacturing software. Automate workflows using Sequencer and Recipes that respond to process changes.
Designed for rapid process development through clinical and commercial manufacturing with single-use, cGMP-ready vessels and audit-ready 21 CFR Part 11-compliant software and IQ/OQ documentation.
Independently control process conditions across each vessel for consistent process development. Closed system, perfusion-capable workflows reduces contamination risk.
The MiniPRO Vertical-Wheel Fluidix™ Vessel
The MiniPRO runs pre-sterilized, closed-system Vertical-Wheel FLUIDIX™ Vessels across up to 24 parallel bioreactors — each with their own pH and DO optical sensors, temperature control, and recipes.
Proven With MiniPRO
Published Vertical-Wheel data at this scale — protocols, app. notes, peer-reviewed papers, case studies, posters, webinars, etc.
This webinar examines scalable suspension culture of PSC-derived organoids using PBS Biotech Vertical-Wheel bioreactors. PBS Applications Engineer, Hannah Worden, explains how low-shear, homogeneous mixing and consistent geometry support organoid process development and scale-up. Case studies cover liver, pancreatic islet, and cerebellar organoids, including aggregate-size control, differentiation, functional markers, and improved organization under dynamic culture. With the audience, we address agitation, seeding density, media formulation, perfusion-based medium exchange, sampling, and…
This poster, presented at ISSCR Kyoto 2026, demonstrates a scalable strategy for iPSC manufacturing using Vertical-Wheel Bioreactors, addressing expansion, process development, cell banking, and differentiation. Linear scale-up from PBS-0.1 through PBS-80 produced 200 billion iPSCs at a 50 L working volume while maintaining pluripotency and normal karyotype. High-density work cell banks were developed through 3D adaptation and retained differentiation potential toward cardiomyocytes and pancreatic progenitors. MiniPRO further served as a controlled scale-down model, demonstrating growth…
This presentation, presented at ISSCR Kyoto 2026 explores how Vertical-Wheel Bioreactors can reduce development and manufacturing risk for PSC therapies by providing a scalable platform from process development through commercial production. It highlights global clinical trials supported by Vertical-Wheel technology, predictive scale-down with MiniPRO, controlled hydrodynamics, automation, and linear scale-up through PBS-80. Data demonstrate consistent PSC growth across scales, culminating in greater than 200 billion cells from a 50 L batch while maintaining pluripotency, illustrating a…
This guide collects and summarizes process parameters from successful experiments performed in Vertical-Wheel® bioreactors, across a variety of cell types including pluripotent stem cells, mesenchymal stem/stromal cells, exosomes and extracellular vesicles, organoids, and immune cells. Find the publication or resource most relevant to your own experiment to help with your process development.
This brochure introduces PBS MiniPRO as an automated, small-scale Vertical-Wheel® Bioreactor system for cell therapy process development. The platform provides dissolved oxygen and pH control, closed-system operation, perfusion-capable workflows, and parallel operation. As a scale-down model of PBS manufacturing-scale Bioreactors, MiniPRO supports predictive process development and technology transfer. The brochure highlights improved process control, reduced variability, streamlined scale-up, and support for workflows requiring consistent aggregate formation and gentle mixing conditions.
This poster evaluates the PBS MiniPRO as a controlled scale-down platform for human induced pluripotent stem cell process development. The system combines four 500 mL Vertical-Wheel vessels with online pH and dissolved oxygen monitoring, gas control, integrated retention filters, perfusion pumps, and closed fluid-handling connections. Experiments examined process reproducibility, direct thaw from high-density cell banks, seed train, commercial and modified media, settlement and perfusion feeding, oxygen control, aggregate morphology, and sampling methods. Controlling dissolved oxygen at 50%…
MiniPRO Parts - (selected parts are added to cart for quote requests)
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We Support You Every Step of the Way
Our application scientists help you get the most out of MiniPRO, and help you plan for what comes next.
Our application scientists optimize cell yield and quality on MiniPRO with you.
Equivalent set points from MiniPRO to PBS-3, CFD-validated at every step.
Guided-optimization packages that move you from R&D to clinical scale.
Go Vertical, Today
Tell us what you need and we’ll take it from there.