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Vertical-Wheel Bioreactors

One Platform, From Research to Commercial

Develop and scale your process with the same gentle Vertical-Wheel® Technology across five single-use bioreactor sizes. From 0.1L R&D to 80L manufacturing, process parameters transfer predictably to support a smoother path to scale.

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Vertical-Wheel Bioreactor Family
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Go VerticalThe Scale-Up Journey

Process Development to Manufacturing Scale-up

Select a stage to explore the system built for it. The same patent-pending Vertical-Wheel FLUIDIX™ mixing physics runs through all of our systems.

Research & pre-clinicalClinical researchCommercial production
Hero Gallery _ PBS-Mini system
PBS-Mini
60mL–0.5L

The quickest way to start developing a scalable cell therapy. PBS-MINI delivers a gentle, low-sheer Vertical-Wheel performance in a compact format: a true scale-down model for larger scales.

Early R&D, PD, and POC processesRepresentative scaled-down modelsQuick-start with kits, protocols, and videos
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The Systems at a Glance

SystemWorking volumeVesselcGMPOPC-UABest for
PBS-Mini60mL–0.5LVertical-Wheel FLUIDIX™ 0.1L & 0.5L Vessels –Early R&D & feasibility screening
PBS-MiniPRO0.3-0.5LVertical-Wheel FLUIDIX™ 0.5L PRO Vessels–DoE, media & feed optimization
PBS-31.8–3LVertical-Wheel FLUIDIX™ 3L VesselsTech transfer & GMP preparation
PBS-159–15LVertical-Wheel FLUIDIX™ 15L VesselsClinical batch capacity
PBS-8045–80LVertical-Wheel FLUIDIX™ 80L VesselsCommercial allogeneic supply
Vertical-Wheel FLUIDIX Vessels

The Purpose-Built Home for Your Cells

Every Vertical-Wheel® Bioreactor runs our Vertical-Wheel FLUIDIX™ Vessels. Pre-sterilized and single-use to keep your culture closed and contamination-free, with the same wheel geometry from 60mL to 80L. Nothing to clean or re-validate between runs.

Consistent geometry across every scale: the mechanism your cells experience never changes.

Closed & single-use: reduces contamination risk and eliminates cleaning validation.

Designed uniquely for every system: PBS-MINI, PBS-MiniPRO, PBS-3, PBS-15, and PBS-80.

Interactive 3D Model
PBS-Mini 0.1L Vessel - 3D
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FA-0.1-D-001 : PBS-MINI 0.1 Vertical Wheel FLUIDIX™ Vessel
Programs

Accelerate Your Process

Bundles, starter packs, and credit redemption make it easy to get started and amplify your efforts.

Guided OptimizationSuccess Bundles

Consulting packages that accelerate your progression from R&D to clinical scale.

Learn more →Jump-Start Your ProcessStarter Packs

Curated PBS-Mini kits paired with big Credit Redemption savings on Success Bundle.

Get started →Amplify Your InvestmentCredit Redemption

Every $1 spent on PBS-Mini products earns $1 - 1.5 credit toward your next scaled-up Vertical-Wheel bioreactor or Success Bundle

Calculate your savings →
Scale-Up Calculator

See Your Set Points at Every Scale

Because Vertical-Wheel scale-up is predictable by design, a small scale working volume and agitation rate maps cleanly to larger bioreactors. Enter your info and get the equivalent set points for the same CFD-validated hydrodynamic conditions at each scale.

Open the Scaling Calculator
Your bench run
Working volume0.5L
Agitation40 rpm
Matched at 15L
Agitation17 rpm
Mean EDRmatched
Illustrative values. Run your own numbers in the calculator.
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Go Vertical, Today

Tell us what you need and we’ll take it from there.