PBS-15 Vertical-Wheel Bioreactor

The PBS-15 Vertical-Wheel^® Bioreactor is the next step in your journey towards commercial manufacturing of cell therapies. Scale up from the PBS-3 with the same proven mixing performance for pilot runs. Recommended for working cell culture volumes ranging from 9 to 15 liters.

Designed for Scale: adjustable height harvest valve (AHHV) supports rapid medium exchange, sampling, and harvest operations
Versatile: single-use or reusable DO and pH sensors and customizable process control
Intuitive: touchscreen interface simplifies process control, customization, and data reporting

PBS-15 Bioreactors vs. Stirred Tank Bioreactors

Feature	Vertical-Wheel Bioreactor	Stirred Tank Bioreactor
Mixing Mechanism	Vertical impeller that generates a gentle, large-scale, upward-and-outward flow.	Horizontal impeller that creates high-shear zones and turbulent eddies.
Shear Stress	Very low. Designed to minimize hydrodynamic stress, making it ideal for shear-sensitive cells like stem cells and cell aggregates.	High, especially near the impeller blades. Can be detrimental to fragile cells, although impeller designs have been optimized to reduce this.
Scalability	Linear. The hydrodynamic conditions remain consistent as the volume increases, allowing for predictable scale-up.	Complex. Scaling up requires careful optimization to maintain consistent conditions, as fluid dynamics change with volume.
Homogeneity	Excellent. The vertical wheel creates a highly uniform environment with eliminating occurrences of high turbulence.	Good. Requires careful design to ensure uniform mixing and prevent gradients, especially in large vessels.
Applications	Primary: Shear-sensitive cell cultures (hiPSCs, MSCs, T-cells), viral vectors, and exosomes	Primary: Large-scale fermentation (bacteria, yeast), and general mammalian cell culture (e.g., CHO cells for biologics).

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Product Parts and Technical Specifications

Product Type	Product Name	Product Number
Bioreactors	PBS-15 Vertical-Wheel Bioreactor, Single-Use Sensors, 120V, Imperial or Metric	IA-15-B-701	Request a quote
Bioreactors	PBS-15 Vertical-Wheel Bioreactor, Single-Use Sensors, 240V, Metric	IA-15-B-702	Request a quote
Accessories	PBS Autoclavable Probe Connector	IA-UNI-DA-001	Request a quote
	Reusable DO Sensor, 12mm OD x 220mm L with Right-Angle	IC00468	Request a quote
	Reusable pH Sensor, 12mm OD x 225mm L	IC00469	Request a quote
Software	PBS-15 Vertical-Wheel Bioreactor Software 3.0 (21 CFR Part 11 cGMP Upgrade)	IA-15-SW-001	Request a quote
Qualification Packages	PBS-15 Vertical-Wheel Bioreactor IQ/OQ Protocols	IA-15-BQ-004	Request a quote
Qualification Packages	PBS-15 Vertical-Wheel Bioreactor IQ/OQ Configuration Sheet	IA-15-BQ-005	Request a quote

Working volume range:	9 – 15 L
Gas control	Mass flow controllers for air, N₂, O₂, CO₂/td>
Vessel Construction	Polyvinylidene Fluoride (PVDF)
Product contact materials	Meet requirements for USP Class VI Testing for Plastics <88> and/or ISO 10993

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Vertical-Wheel Bioreactor
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The PBS Mini Bioreactor 90 Day Guarantee

If you are not satisfied with the performance of the PBS-Mini products or accessories get your money back. Must show necessary performance documentation to qualify.