PBS Biotech Unveils a Breakthrough Product for Cell Therapy Process Development at ISSCR, Boston
This press release announces the launch of MiniPRO™, a multi-parallel Vertical-Wheel® Bioreactor platform for high-throughput cell therapy process development and scale-up. The system supports up to 24 independent cultures in an automated, closed environment with real-time monitoring and control of temperature, agitation, pH, dissolved oxygen, and perfusion medium exchange. Designed to mirror the hydrodynamic performance of larger GMP-ready Vertical-Wheel® Bioreactors, MiniPRO supports process transfer and scale-up confidence. The platform is intended to accelerate process optimization, reduce development costs, and bridge research and clinical manufacturing.
The PBS Closed-System Sampling Conical supports aseptic, representative sample collection from PBS Vertical-Wheel® Bioreactors while maintaining process integrity and sample quality. The single-use assembly combines a gamma-irradiated vented conical, integrated dip tube, and weldable tubing to reduce contamination risk, handling steps, and operator variability. Compatible with stem cells, immune cells, organoids, and aggregate cultures, it supports routine in-process analyses including cell counts, viability testing, metabolite monitoring, and aggregate characterization.
This flyer describes the PBS Biotech CDMO Partner Program, which provides flexible access to PBS-3 and MiniPRO Vertical-Wheel® Bioreactor systems through lease-to-own, installment, and on-demand acquisition models. The program helps CDMOs, CMOs, and process-development organizations expand cell therapy capabilities while reducing upfront capital requirements. Participants receive training, onboarding, technical support, and commercial collaboration opportunities. Program structures, deployment options, partner tiers, and qualification pathways are designed to support manufacturing capacity…
This publication characterizes aeration, oxygen transfer, mixing, and hydrodynamics in Vertical-Wheel™ Bioreactors using experimental measurements and computational fluid dynamics. The study evaluates oxygen mass transfer coefficients, velocity distributions, energy dissipation rates, shear profiles, and fluid flow under multiple operating conditions. Predictive models describe oxygen transport and mixing performance while assessing the effects of agitation. Results demonstrate efficient mixing and oxygen distribution while maintaining hydrodynamic conditions suitable for sensitive cell…
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