PBS-80 Bioreactor Datasheet
This data sheet provides an overview of the PBS-80 Vertical-Wheel® single-use Bioreactor System for large-scale cell therapy manufacturing. It highlights homogeneous mixing, low-shear suspension, integrated controls, scalable process performance, and customizable single-use fluid paths. Technical specifications cover working volume, agitation, gas delivery, process sensors, pumps, software, control architecture, and bag construction. The document supports evaluation of PBS-80 for clinical and commercial manufacturing applications requiring controlled, scalable, and reproducible bioprocess performance.
The PBS Closed-System Sampling Conical supports aseptic, representative sample collection from PBS Vertical-Wheel® Bioreactors while maintaining process integrity and sample quality. The single-use assembly combines a gamma-irradiated vented conical, integrated dip tube, and weldable tubing to reduce contamination risk, handling steps, and operator variability. Compatible with stem cells, immune cells, organoids, and aggregate cultures, it supports routine in-process analyses including cell counts, viability testing, metabolite monitoring, and aggregate characterization.
This application note describes an hMSC manufacturing workflow using RoosterBio cell products, xeno-free media, and PBS Biotech Vertical-Wheel bioreactors. Studies evaluated microcarrier culture, fed-batch operation, harvest, scale-up, and cell quality. The low-shear, uniformly mixed environment supported robust attachment and cell densities up to 500,000 cells/mL within five days. Fed-batch processing improved media productivity by eliminating routine media exchanges and reducing labor. Comparable growth and metabolite control were maintained across development, pilot, and production…
This publication combines oxygen-transfer rate measurements through surface aeration for Vertical-Wheel bioreactors with specific oxygen-uptake measurements from human induced pluripotent stem cell aggregate cultures. Oxygen mass-transfer coefficients (kLa) were measured under different agitation rates, working volumes and headspace gas-flow conditions in 3, 15 and 80 L systems. The specific oxygen-uptake rate of iPSC aggregates was measured in a 0.1 L bioreactor using a custom dissolved oxygen probe configuration. These datasets were combined to estimate the theoretical maximum cell…
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